What's the big issue?
何が問題なんだ；問題ないじゃないか
What's the date (today)?＝What's today's date?＝What date is it (today)?
今日は何日ですか
What's the hurry?＝Why all the hurry?
なぜそんなに急ぐのか
What's the matter (with you)?
((略式))どうかした？
What's the matter?
どうかしたの
What's the meaning of life?
人生の意義とは何か
What's the point (in [of]) doing that?
そんなことして何になるのか（何にもなりはしない）
What's the real reason for his strange behavior?
彼の奇妙な態度のほんとうの理由はなんですか
What's the score, doctor?
先生，本当のところどうなんですか
What's the yen-dollar rate today?
今日の円ドルレートはいくらですか
