A large crowd collected around me.
大勢の人に取り囲まれた
A large debt is weighing heavily on him [his shoulders, his mind].
多額の負債が彼には重い負担だ
a large flock of pigeons
ハトの大群
a large heart
大らかな心
a large [small] house
大ぜいの[少ない]観衆
a large issue [question]
大問題
a large number of people
たくさんの人々
a large pan
大型フライパン
a large [good] part of one's money
持ち金の大半
A large pile of mail had accumulated while we were away on a trip.
旅行に出ている間に郵便の山ができていた